Kaposi's Sarcoma is a cancerous lesion that can occur on the soles of the feet. The lesion is irregular in shape and has a purplish, reddish or bluish black appearance. Kaposi's Sarcoma lesions tend to spread and form large plaques or become nodular. The nodular lesions have a firm rubbery appearance. The disease is usually associated with AIDS infection. It can occur without the concurrent AIDS infection, but this is very rare.

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| About 60-70% of people with diabetes have mild to severe forms of diabetic nerve damage, which in severe forms can lead to lower limb amputations. Approximately 56,000 people a year lose their foot or leg to diabetes. |
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